Humoral Response against Native Plasmodium berghei Hemozoin and Synthetic Hemozoin in BALB/c Mice
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چکیده
منابع مشابه
Quantitative characterization of hemozoin in Plasmodium berghei and vivax
The incidence and global distribution of chloroquine resistant (CR) Plasmodium vivax infection has increased since emerging in 1989. The mechanism of resistance in CR P. vivax has not been defined. The resistance likely relates to the formation and disposition of hemozoin as chloroquine's primary mechanism of action involves disruption of hemozoin formation. CR P. berghei strains, like CR P. vi...
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Hemozoin (Hz) is released into the blood stream after rupture of infected red blood cells (iRBCs) at the end of each parasite replication cycle. This free Hz is ingested by circulating and resident phagocytes. The presence of Hz in tissues after clearance of infection has been previously reported. Still, little is known about the kinetics of Hz in vivo, during and after Plasmodium infection. It...
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Increasing evidence points to an important role for hemozoin (HZ), the malaria pigment, in the immunopathology related to this infection. However, there is no consensus as to whether HZ exerts its immunostimulatory activity in absence of other parasite or host components. Contamination of native HZ preparations and the lack of a unified protocol to produce crystals that mimic those of Plasmodiu...
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which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 33-year-old man presented with left hypochondrium pain and high-grade fever for 1 week and generalized convulsions followed by persistent unconsciousness. 2.8 mg/dL. His coagulation profile showed an international normalized ratio of 2.4, along with severe...
متن کاملProtein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum.
Malaria parasites use hemoglobin (Hb) as a major nutrient source in the intraerythrocytic stage, during which heme is converted to hemozoin (Hz). The formation of Hz is essential for parasite survival, but to date, the underlying mechanisms of Hb degradation and Hz formation are poorly understood. We report the presence of a ∼200-kDa protein complex in the food vacuole that is required for Hb d...
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ژورنال
عنوان ژورنال: British Journal of Medicine and Medical Research
سال: 2014
ISSN: 2231-0614
DOI: 10.9734/bjmmr/2014/5561